Takk for interessant graving Frontmast, men hva er egentlig nytt og hva mener du de skjuler? Fint om du kan trekke noen konklusjoner også sammenfattet i korthet.

Merk dere nedenstående sitat fra en av linkene, metalliske isotoper (177 Lu) mot CD37 er altså tingen:

Previous studies thus show that CD37 is a potent target for both immunotherapy and RIT. The chloramine T method of 131 I-labeling was used in the early studies of CD37 RIT described above. 131 I labeled to antibodies with the iodogen or the chloramine T method are not being contained in the cells if the antigen-antibody complex is internalized. Inside the cells the nuclide is removed from the antibody by intracellular enzymes and diffuses out and away from the tumour cells. The same so-called dehalogenation has been shown with CD22 antibodies, which are also internalized. Metallic radionuclides labeled to antibodies with so-called chelators are however more stable and remain contained inside the cells to a much higher degree. By using metallic radionuclides internalizing antigens can be used for tumour targeting and tumour uptake may also be higher than for non-internalizing antibodies as well.

At the Norwegian Radium Hospital, an antibody (lilotomab also called HH1) was developed against CD37 in the 1980's. Lilotomab and the anti-CD20 antibody rituximab have been labeled with both 125 I and m In and measured cell bound activity after 4 days of incubation with a lymphoma cell line. The results show that the problem of catabolism of RIC can be circumvented by labeling with metallic nuclides such as m In or 177 Lu.

Helt generelt kan man si at selskaper drøyer å melde dårlige nyheter så lenge som mulig. Gode nyheter meldes når de kommer. Hvis selskapet skjuler noe så er det i allefall ikke gode nyheter for å si det sånn.

Dette er egentlig helt forbilledlig. Forskningsresultater skal presenteres i tidsskrifter og på kongresser slik Costa sa.

Frontmast:

Hørte ikke noe mer fra deg. Hva er egentlig viktig nytt i det du har funnet og hva mener du ledelsen skjuler, om noe i det hele tatt?